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Modified Nucleosides: in Biochemistry, Biotechnology and Medicine
£325.00

MODIFIED NUCLEOSIDES: IN BIOCHEMISTRY, BIOTECHNOLOGY AND MEDICINE

HARDBACK BY HERDEWIJN, PIET

£325.00

ISBN
9783527318209
IMPRINT
WILEY-VCH VERLAG GMBH
 
 
EDITION
PUBLISHER
WILEY-VCH VERLAG GMBH
STOCK FOR DELIVERY
NOT IN STOCK - AVAILABLE TO ORDER
FORMAT
HARDBACK
PAGES
684 pages
PUBLICATION DATE
13 AUG 2008

DESCRIPTION

Edited by one of the main driving forces behind the field's momentous rise in recent years, this one-stop reference is the first comprehensive resource to integrate recent advances. The first part addresses biochemical aspects and applications, the second and third parts are devoted to compounds with therapeutic potential, with the third part focusing on newly introduced anticancer nucleoside drugs. Essential reading for every scientist working in this area.

CONTENTS

BIOCHEMISTRY AND BIOPHYSICS Investigations on Fluorine-labeled Ribonucleic Acids by 19F-NMR Spectroscopy 8-Oxo-7,8-dihydro-2'-deoxyguanosine, a major DNA oxidation product Modified DNA Bases: Probing Base Pair Recognition by Polymerases 2'-Deoxyribose Modified Nucleoside Triphosphates and their Recognition by DNA Polymerases Pyrimidine Dimers: UV-induced DNA Damage Locked Nucleic Acids: Properties, Applications and Perspectives Studies on the synthesis and properties of oligonucleotides incorporating modified nucleobases capable for the formation of Watson and Crick type base pairs The Properties of 4'-Thionucleosides S-Adenosyl-L-methionine and related compounds BIOTECHNOLOGY 5-Subsituted nucleosides in biochemistry and biotechnology Universal base analogues and their applications to biotechnology MEDICINAL CHEMISTRY The Properties of Locked Methanocarba Nucleosides in Biochemistry, Biotechnology and Medicinal Chemistry Synthesis, chemical properties and biological activities of cyclic bis(3'-5')diguanylic acid (c-di-GMP) and its analogues Siderophore Biosynthesis Inhibitors Synthesis and Biological Activity of Selected Carbocyclic Nucleosides 4'-C-Ethynyl-2'-deoxynucleosides Modified nucleosides as Selective Modulators of Adenosine Receptors for Therapeutic Use The Design of Forodesine HCl and Other Purine Nucleoside Phosphorylase Inhibitors Formycin and Analogues: Purine Nucleoside Phosphorylase Inhibitors and their Potential Application in Immunosuppression and cancer 1-(3-C-Ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd) Syntheses and Biological Activity of Neplanocin and Analogues Clitocine and Its Analogs ANTITUMORALS AND ANTIVIRALS Capecitabine Preclinical Studies: From Discovery to Translational Research Tenofovir and Adefovir as Antiviral Agents Clofarabine: Design to Approval